Several clinical trials of Staphylococcus aureus (S. aureus)‒targeted therapies for atopic
dermatitis (AD) have shown conflicting results about whether they improve AD severity
scores. This study performs a model-based meta-analysis to investigate the possible causes
of these conflicting results and suggests how to improve the efficacies of S. aureus‒targeted
therapies. We developed a mathematical model that describes systems-level AD
pathogenesis involving dynamic interactions between S. aureus and coagulase-negative …