[HTML][HTML] The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation
Y Li, D Yang, N Tian, P Zhang, Y Zhu, J Meng… - Journal of Biological …, 2019 - ASBMB
The glucose-responsive transcription factor carbohydrate response element–binding protein
(ChREBP) critically promotes aerobic glycolysis and cell proliferation in colorectal cancer
cells. It has been reported that ubiquitination may be important in the regulation of ChREBP
protein levels and activities. However, the ChREBP-specific E3 ligase and molecular
mechanism of ChREBP ubiquitination remains unclear. Using database exploration and
expression analysis, we found here that levels of the E3 ligase SMURF2 (Smad …
(ChREBP) critically promotes aerobic glycolysis and cell proliferation in colorectal cancer
cells. It has been reported that ubiquitination may be important in the regulation of ChREBP
protein levels and activities. However, the ChREBP-specific E3 ligase and molecular
mechanism of ChREBP ubiquitination remains unclear. Using database exploration and
expression analysis, we found here that levels of the E3 ligase SMURF2 (Smad …
