Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity
The transcription factor NFκB plays a critical role in normal and pathophysiological immune
responses. Therefore, NFκB and the signaling pathways that regulate its activation have
become a major focus of drug development programs. Withania somnifera (WS) is a
medicinal plant that is widely used in Palestine for the treatment of various inflammatory
disorders. In this study we show that the leave extract of WS, as well as its major constituent
withaferin A (WA), potently inhibits NFκB activation by preventing the tumor necrosis factor …
responses. Therefore, NFκB and the signaling pathways that regulate its activation have
become a major focus of drug development programs. Withania somnifera (WS) is a
medicinal plant that is widely used in Palestine for the treatment of various inflammatory
disorders. In this study we show that the leave extract of WS, as well as its major constituent
withaferin A (WA), potently inhibits NFκB activation by preventing the tumor necrosis factor …