Identification and characterization of latency-associated peptide-expressing γδ T cells
Nature communications, 2015•nature.com
Abstract γδ T cells are a subset of lymphocytes specialized in protecting the host against
pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the
latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+ IFN-γ+
CCR9+ α4β7+ TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and
small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3
expression and acquire a regulatory phenotype. TCRγδ+ LAP+ cells express antigen …
pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the
latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+ IFN-γ+
CCR9+ α4β7+ TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and
small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3
expression and acquire a regulatory phenotype. TCRγδ+ LAP+ cells express antigen …
Abstract
γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer’s patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease.
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