[HTML][HTML] Interpreting NK cell transcripts versus T cell transcripts in renal transplant biopsies
NK cell transcripts are increased in biopsies with antibody-mediated rejection, whereas T
cell transcripts are increased in T cell-mediated rejection. However, NK and T cells share
many features, creating potential ambiguity. Therefore to estimate the NK-versus T cell
transcript burdens separately, we defined nonoverlapping transcripts selective for NK cells
(N= 4) or T cells (N= 5). We compared NK-versus T cell transcript burdens in microarrays
from 403 kidney transplant biopsies (182 early, 221 late). In late biopsies, high NK-cell …
cell transcripts are increased in T cell-mediated rejection. However, NK and T cells share
many features, creating potential ambiguity. Therefore to estimate the NK-versus T cell
transcript burdens separately, we defined nonoverlapping transcripts selective for NK cells
(N= 4) or T cells (N= 5). We compared NK-versus T cell transcript burdens in microarrays
from 403 kidney transplant biopsies (182 early, 221 late). In late biopsies, high NK-cell …
